摘要 背景与目的:胰腺癌临床起病隐匿,患者确诊时大多数已属晚期,失去了根治性治疗的机会。因此,寻找一种新的生物标志物用于胰腺癌的诊断具有重要意义。本研究探讨胰腺癌患者血清血管生成素样蛋白2(ANGPTL2)与病理特征的关系及其在胰腺癌诊断中的价值。方法:比较125例胰腺癌患者和66例健康体检者血清ANGPTL2水平;用统计学方法分析胰腺癌患者血清ANGPTL2水平高低与临床病理参数、CA19-9水平的关系以及胰腺癌的危险因素;采用ROC曲线分析血清ANGPTL2、血清CA19-9以及两者联合检测对胰腺癌的诊断效能。结果:胰腺癌患者血清平均ANGPTL2水平明显高于健康人群(6.52 ng/mL vs.3.78 ng/mL,P<0.05);胰腺癌患者血清ANGPTL2水平与肿瘤的大小、组织学分级、淋巴结转移和TNM分期密切有关(均P<0.05),而与性别、年龄、远处转移无关(均P>0.05);血清ANGPTL2水平与CA19-9水平呈明显正相关(r=0.772,P<0.001);单因素分析和多因素分析显示,糖尿病(P=0.016)和ANGPTL2(P=0.014)是引起胰腺癌的独立危险因素;血清ANGPTL2、CA19-9及两者联合检测对胰腺癌诊断的AUC分别为0.939、0.953、0.966,特异度与阳性预测值分别为92.4%与95.7%、84.8%与91.9%、98.5%与96.4%。结论:胰腺癌患者血清ANGPTL2水平升高,其表达与临床病理特征密切相关;ANGPTL2与CA19-9联合检测对胰腺癌的诊断具有一定价值。 Background and Aims:The onset of pancreatic cancer is insidious and most of the patients were diagnosed at an advanced stage,thus losing the chance of radical treatment.Therefore,finding a new biomarker for the diagnosis of pancreatic cancer is of great significance.This study was conducted to investigate the association of the serum angiopoietin-like protein 2(ANGPTL2)in pancreatic cancer patients with the clinicopathologic characteristics and its application value in diagnosis of pancreatic cancer.Methods:Serum ANGPTL2 levels between 125 pancreatic cancer patients and 66 healthy subjects were compared.The relations of serum ANGPTL2 level with the clinicopathologic variables and CA19-9 level as well as the risk factors for pancreatic cancer were analyzed by statistical methods.ROC curve was used to analyze the diagnostic abilities of serum ANGPTL2,serum CA19-9 and their combined detection for pancreatic cancer.Results:The average serum level of ANGPTL2 in pancreatic cancer patients was significantly higher than that in healthy individuals(6.52 ng/mL vs.3.78 ng/mL,P<0.05).The serum ANGPTL2 level in pancreatic cancer patients was significantly related to tumor size,histological grade,lymph node metastasis and TNM stage(all P<0.05),and irrelevant to sex,age and distant metastasis(all P>0.05).There was a significant positive correlation between serum ANGPTL2 level and CA19-9 level(r=0.772,P<0.001).Univariate and multivariate analysis showed that diabetes mellitus(P=0.016)and ANGPTL2(P=0.014)were independent risk factors for pancreatic cancer.The AUC values of serum ANGPTL2,CA19-9 and their combined detection for diagnosis of pancreatic cancer were 0.939,0.953 and 0.966,with the specificity/positive predictive value of 92.4%/95.7%,84.8%/91.9%,and 98.5%/96.4%.Conclusion:Serum ANGPTL2 level is elevated in pancreatic cancer patients.The ANGPTL2 level is closely related to the clinicopathologic features.The combined detection of ANGPTL2 and CA19-9 has certain value in diagnosis of pancreatic cancer.
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2021年第3期254-260,共7页 Chinese Journal of General Surgery
基金 国家自然科学基金资助项目(81860508) 广西自然科学基金资助项目(2018GXNSFAA138026) 广西壮族自治区卫生和计划生育委员会基金资助项目(Z20180950) 广西南宁市武鸣区科学研究与技术开发计划资助项目(20190403) 广西医疗卫生适宜技术开发与推广应用基金资助项目(S2018040)。
关键词 胰腺肿瘤 血管生成素样蛋白质类 血清学试验 生物标记 肿瘤 Pancreatic Neoplasms Angiopoietin-like Proteins Serologic Tests Biomarkers Tumor
分类号 R735.9 [医药卫生—肿瘤]
